全文获取类型
收费全文 | 20131篇 |
免费 | 1445篇 |
国内免费 | 429篇 |
专业分类
耳鼻咽喉 | 383篇 |
儿科学 | 379篇 |
妇产科学 | 328篇 |
基础医学 | 3240篇 |
口腔科学 | 245篇 |
临床医学 | 1649篇 |
内科学 | 4461篇 |
皮肤病学 | 791篇 |
神经病学 | 1482篇 |
特种医学 | 1495篇 |
外科学 | 2600篇 |
综合类 | 129篇 |
一般理论 | 5篇 |
预防医学 | 693篇 |
眼科学 | 544篇 |
药学 | 1614篇 |
中国医学 | 258篇 |
肿瘤学 | 1709篇 |
出版年
2023年 | 89篇 |
2022年 | 71篇 |
2021年 | 556篇 |
2020年 | 389篇 |
2019年 | 512篇 |
2018年 | 604篇 |
2017年 | 509篇 |
2016年 | 780篇 |
2015年 | 1104篇 |
2014年 | 1261篇 |
2013年 | 1348篇 |
2012年 | 1954篇 |
2011年 | 1864篇 |
2010年 | 1234篇 |
2009年 | 1019篇 |
2008年 | 1302篇 |
2007年 | 1187篇 |
2006年 | 1043篇 |
2005年 | 922篇 |
2004年 | 728篇 |
2003年 | 667篇 |
2002年 | 584篇 |
2001年 | 258篇 |
2000年 | 256篇 |
1999年 | 182篇 |
1998年 | 172篇 |
1997年 | 157篇 |
1996年 | 114篇 |
1995年 | 94篇 |
1994年 | 73篇 |
1993年 | 79篇 |
1992年 | 64篇 |
1991年 | 78篇 |
1990年 | 55篇 |
1989年 | 78篇 |
1988年 | 89篇 |
1987年 | 66篇 |
1986年 | 48篇 |
1985年 | 45篇 |
1984年 | 34篇 |
1983年 | 34篇 |
1982年 | 27篇 |
1981年 | 17篇 |
1980年 | 29篇 |
1979年 | 30篇 |
1978年 | 29篇 |
1977年 | 44篇 |
1976年 | 24篇 |
1975年 | 25篇 |
1973年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
61.
K.-C. Sung D.-C. Seo S.-J. Lee M.-Y. Lee S.H. Wild C.D. Byrne 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2019,29(5):489-495
Background and aims
It is not known whether non alcoholic fatty liver disease (NAFLD) is a risk factor for diabetes in non obese, non centrally-obese subjects. Our aim was to investigate relationships between fatty liver, insulin resistance and a biomarker score for liver fibrosis with incident diabetes at follow up, in subjects who were neither obese nor centrally-obese.Methods and results
As many as 70,303 subjects with a body mass index (BMI) < 25 kg/m2 and without diabetes were followed up for a maximum of 7.9 years. At baseline, fatty liver was identified by liver ultrasound, insulin resistance (IR) by homeostatic model assessment of insulin resistance (HOMA-IR) ≥2.0, and central obesity by waist circumference (waist circumference ≥90 cm (men) and ≥85 cm (women). The Fibrosis-4 (FIB-4 score) was used to estimate extent of liver fibrosis. Cox proportional hazards models adjusted for confounders were used to estimate hazard ratios (aHRs) for incident diabetes. As many as 852 incident cases of diabetes occurred during follow up (median [IQR] 3.71 [2.03] years). Mean ± SD BMI was 22.8 ± 1.8 and 21.7 ± 2.0 kg/m2 in subjects with and without diabetes at follow up. In subjects without central obesity and with fatty liver, aHRs (95% CI) for incident diabetes at follow up were 2.17 (1.56, 3.03) for men, and 2.86 (1.50,5.46) for women. Similar aHRs for incident diabetes occurred with fatty liver, IR and the highest quartile of FIB-4 combined, in men; and there was a non significant trend toward increased risk in women.Conclusions
In normal weight, non-centrally obese subjects NAFLD is an independent risk factor for incident diabetes. 相似文献62.
63.
64.
65.
Kun‐Yong Sung Seungkoo Lee Yeonjin Jeong Sang‐Yeul Lee 《The Australasian journal of dermatology》2021,62(1):60-63
A classic pilomatricoma, which usually presents with an asymptomatic, solitary, firm, subcutaneous nodule in the head, neck, or extremities of the paediatric population, is easily diagnosed based on its characteristic clinical and histopathological features. However, its variants often pose particular diagnostic challenges to clinicians due to their rarity and diverse clinicopathological features. We present a new pseudocystic variant, manifesting as solid lesions floating in a fluid‐filled sac. 相似文献
66.
T.-Y. Huang Y.-J. Hsia M.-Y. Sung Y.-T. Wu P.-C. Hsu 《International journal of oral and maxillofacial surgery》2021,50(8):1100-1106
Zygomatic implant treatment is widely applied for severe maxillary atrophy to help rehabilitate the maxillary dentition. This retrospective study was performed to evaluate the actual radiographic bone–implant contact (rBIC) lengths of zygomatic implants. The records of 28 patients who underwent zygomatic implant surgery and subsequent follow-up examinations between August 2013 and September 2018 in the Department of Oral and Maxillofacial Surgery, Taipei Tzu Chi Hospital were reviewed. The surgeries were performed by a single surgeon using the same treatment protocol. All patients had a computed tomography scan at 1 year after the surgery. Using three-dimensional imaging software, an investigator measured the rBIC lengths of 66 implants and documented their clinical status. The implant survival rate was 100%. The mean rBIC length was significantly longer in male patients than in female patients (20.80 ± 5.88 mm versus 17.79 ± 6.34 mm; P = 0.028). The mean rBIC length of double zygomatic implants was significantly longer when compared to that of single implants (21.11 ± 6.23 mm versus 17.75 ± 5.85 mm; P = 0.027). This article is novel in reporting the exact rBIC lengths of zygomatic implants in a clinical setting. The results showed that zygomatic implants are a viable treatment modality for full-mouth rehabilitation. 相似文献
67.
68.
Ye Young Shin Yoojin Seo Su-Jeong Oh Ji-Su Ahn Min-hye Song Min-Jung Kang Jung-Min Oh Dongjun Lee Yun Hak Kim Eui-Suk Sung Hyung-Sik Kim 《Journal of pineal research》2022,72(1):e12779
The prevalence of head and neck squamous cell carcinoma (HNSCC) has continued to rise for decades. However, drug resistance to chemotherapeutics and relapse, mediated by cancer stem cells (CSCs), remains a significant impediment in clinical oncology to achieve successful treatment. Therefore, we focused on analyzing CSCs in HNSCC and demonstrated the effect of melatonin (Mel) and verteporfin (VP) on SCC-25 cells. HNSCC CSCs were enriched in the reactive oxygen species-low state and in sphere-forming cultures. Combination treatment with Mel and VP decreased HNSCC viability and increased apoptosis without causing significant damage to normal cells. Sphere-forming ability and stem cell population were reduced by co-treatment with Mel and VP, while mitochondrial ROS level was increased by the treatment. Furthermore, the expression of mitophagy markers, parkin and PINK1, was significantly decreased in the co-treated cells. Mel and VP induced mitochondrial depolarization and inhibited mitochondrial function. Parkin/TOM20 was localized near the nucleus and formed clusters of mitochondria in the cells after treatment. Moreover, Mel and VP downregulated the expression of markers involved in epithelial-mesenchymal transition and metastasis. The migration capacity of cells was significantly decreased by co-treatment with Mel and VP, accompanied by the down-regulation of MMP-2 and MMP-9 expression. Taken together, these results indicate that co-treatment with Mel and VP induces mitochondrial dysfunction, resulting in the apoptosis of CSCs. Mel and VP could thus be further investigated as potential therapies for HNSCC through their action on CSCs. 相似文献
69.
Sunyoung Kim Chang Won Won Byung Sung Kim Hyun Rim Choi Min Young Moon 《Journal of Korean medical science》2014,29(7):995-1000
The purpose of this study was to predict osteoporosis risk as decreasing muscle mass and to declare the cut-off value of low muscle mass in an elderly Korean population. This study was based on data from the 2008-2010 Korea National Health and Nutritional Examination Surveys (KNHANES). The subjects included 1,308 men and 1,171 women over 65 yr. Bone mineral density (BMD) and appendicular skeletal muscle (ASM) were measured by dual energy X-ray absorptiometry (DXA), and appendicular skeletal muscle was adjusted by height as a marker of sarcopenia. After confirming the correlation between low muscle mass and BMD, the best cut-off value of muscle mass to estimate osteoporosis was suggested through the receiver operating characteristic (ROC) curve. For both men and women, BMD correlated positively with low muscle mass when ASM/Ht2 was used as a marker for sarcopenia. The ROC curve showed that ASM/Ht2 was the best marker for osteoporosis at a cut-off value of 6.85 kg/m2 for men and 5.96 kg/m2 for women. When these cut-off values were used to determine sarcopenia, the risk of osteoporosis increased 4.14 times in men and 1.88 times in women. In particular, men (OR 2.12) with sarcopenia were more greatly affected than women (OR 1.15), even after adjusting for osteoporosis risk factors. In elderly Korean people, sarcopenia is positively correlated with BMD and there is a strong correlation between sarcopenia and osteoporosis with risk of bone fracture. 相似文献
70.
Geum‐Jun Han Jae‐Hoon Kim Sung‐No Chung Bae‐Hyeock Chun Chang‐Keun Kim Deog‐Gyu Seo Ho‐Hyun Son Byeong‐Hoon Cho 《European journal of oral sciences》2014,122(6):417-423
This study investigated the effect of low‐power, non‐thermal atmospheric pressure plasma (NT‐APP) treatments, in pulsed and conventional modes, on the adhesion of resin composite to dentin and on the durability of the bond between resin composite and dentin. A pencil‐type NT‐APP jet was applied in pulsed and conventional modes to acid‐etched dentin. The microtensile bond strength (MTBS) of resin composite to dentin was evaluated at 24 h and after thermocycling in one control group (no plasma) and in two experimental groups (pulsed plasma and conventional plasma groups) using the Scotchbond Multi‐Purpose Plus Adhesive System. Data were analyzed using two‐factor repeated‐measures anova and Weibull statistics. Fractured surfaces and the bonded interfaces were evaluated using a field‐emission scanning electron microscope. Although there were no significant differences between the plasma treatment groups, the plasma treatment improved the MTBS compared with the control group. After thermocycling, the MTBS did not decrease in the control or conventional plasma group but increased in the pulsed plasma group. Thermocycling increased the Weibull moduli of plasma‐treated groups. In conclusion, plasma treatment using NT‐APP improved the adhesion of resin composite to dentin. Using a pulsed energy source, the energy delivered to the dentin was effectively reduced without any reduction in bond strength or durability. 相似文献